CHR 6494 trifluoroacetate

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2250

CAS [1458630-17-5]

MF C16H16N6.C2HF3O2
MW 406.36

  • Purity: 99%
  • Soluble in DMSO

CHR 6494 trifluoroacetate


Specific, first-in-class inhibitor of histone kinase Haspin, which blocks H3T3 phosphorylation in association with a characteristic spindle and centrosome phenotype (IC50 values are 500 nM, 473 nM and 752 nM for apoptosis induction in HCT-116, HeLa and MDA-MB-231 cells, respectively). CHR 6494 causes arrest in G2/M, induces apoptosis and possesses ex vivo anti-angiogenesis features and antitumoral properties in a nude mice xenograft model. Haspin function is critical in mitosis, favouring chromosome cohesion, metaphase alignment and progression through the cell cycle.
Size Unit Price Stock
10 mg €120.00 In Stock
50 mg €480.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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