GSK 2256294A - GSK 2256294

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2220

CAS [1142090-23-0]

MF C21H24F3N7O
MW 447.46

  • Purity: 99%
  • Optical purity: Optically pure (absolute stereochemistry)
  • Soluble in DMSO

GSK 2256294A

Description

GSK2256294A is a potent, reversible, tight binding inhibitor of isolated recombinant human sEH (IC50 value 27 pM), and displays potent inhibition against the rat (IC50 = 61 pM) and murine (IC50 = 189 pM) orthologs of sEH. GSK2256294A also displays potent cellular inhibition (IC50 = 0.66 nM) of sEH in a cell line transfected with the human sEH enzyme.The selectivity of the compound has been demonstrated by testing against a large panel of enzymes, receptors and ion channels, including the phosphatase activity of EPHX2.
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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