ASK1 Inhibitor 10

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2179

CAS [1005775-56-3]

MF C21H21N5O.2HCl
MW 432.35

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

ASK1 Inhibitor 10

Description

Potent, selective, and orally bioavailable ASK1 inhibitor (IC50: 14 nM) with no affinity for a representative panel of kinases (IC50: >10 μM), except for ASK2 (IC50: 0.51 μM). Compound 10 shows a high ligand-lipophilicity efficiency (LLE, pIC50–logD = 4.69) value, which avoids issues of undesirable physical properties and ADME (absorption, distribution, metabolism, and elimination) profiles and interactions with other protein kinases and adverse biological activities.
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Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €450.00 In Stock
Special Offers
Size Unit Price Stock
2 x 10 mg €200.00 In Stock
2 x 50 mg €740.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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