R 428 dihydrochloride - BGB324

Based on 160 publications in PubMed 10 10 160

Axon 1946

CAS [N.A.]

MF C30H34N8.2HCl
MW 579.57

  • Purity: 99%
  • Optical purity: 99% ee
  • Soluble in water and DMSO

R 428 dihydrochloride

Description

Potent and selective inhibitor of Axl receptor tyrosine kinases (IC50: 14 nM); R428 inhibits Axl kinase and blocks Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production.

Note: The hydrochloride salt of R428 is water-soluble and has an improved solubility in DMSO in comparison with its free base

KEYWORDS: R 428 dihydrochloride | supplier | Axl inhibitor | BGB324 | R428 HCl | R-428 | BGB-324 | CAS [1037624-75-1] | Gas6 | Axl | receptor tyrosine kinase | RTK | Akt | breast cancer | proinflammatory | cytokine production

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Size Unit Price Stock
1 mg €95.00 In Stock
2 mg €135.00 In Stock
5 mg €195.00 In Stock
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2 x 5 mg €300.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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