SSR 125543A - SSR 125543 hydrochloride

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1799

CAS [321839-75-2 ]

MF C27H28ClFN2OS.HCl
MW 519.50

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in DMSO

SSR 125543A

Description

Potent, selective, and orally active corticotropin-releasing factor 1 receptor (CRF1) antagonist (pKi values of 8.73 and 9.08 for human cloned or native CRF1 receptors, respectively) with antidepressant-like and anxiolytic-like effects in the Flinders Sensitive Line rats. SSR 125543A shows a 1000-fold selectivity for CRF1 versus CRF2α receptor and CRF binding protein, has a long duration of action, and readily crosses the blood-brain barrier.
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5 mg €160.00 In Stock
25 mg €580.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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