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SA 4503
- Cutamesine
Axon 1767
- Parent CAS: 165377-43-5
Purity:
99%
- Soluble in water
- MF: C23H32N2O2.2HCl
- MW: 441.43
Description
SA 4503 is a potent and selective sigma-1 receptor agonist with high affinity for sigma-1 receptors (IC50: 17.4 nM) and approximately 100-fold lower affinity for sigma-2 receptors.
Sigma-1 receptors modulate ER-mitochondrial signaling, ion channel function, neurotransmission and cellular stress responses. SA 4503 is useful for studying sigma-1 receptor activation in neuropharmacology and cytoprotective signaling models.
Key Features
- Potent sigma-1 receptor agonist
- IC50: 17.4 nM for sigma-1 receptor binding
- Approximately 100-fold selective over sigma-2 receptors
- Useful CNS sigma receptor pharmacology tool
Applications
- Sigma-1 receptor pharmacology
- Neuroprotection and stress-response studies
- CNS neurotransmission models
- GPCR-like receptor binding and selectivity assays
More Information
| Parent CAS No. | 165377-43-5 |
|---|---|
| Chemical Name | 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride |
| SMILES | N1(CCC2=CC=C(OC)C(OC)=C2)CCN(CCCC2=CC=CC=C2)CC1.Cl.Cl |
| MFCD | MFCD00939308 |
| InChi | InChI=1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H |
| InChiKey | XWOXAKBQEMQMFH-UHFFFAOYSA-N |
| CID | 9954941 |
| Short Description | Sigma-1 antagonist |
SA 4503
potent sigma-1 receptor agonist
Cutamesine
SA4503
SA-4503
Sigma-1
sigma-1 receptor
Sigma receptor substrates
Agonist
GPCR signaling
Sigma-1 receptor pharmacology
Neuroprotection and stress-response studies
CNS neurotransmission models
GPCR-like receptor binding and selectivity assays
mitochondrial function
GPCR pharmacology
ion channel pharmacology
receptor selectivity
signal transduction
CNS
GPCR
CAS 165377-44-6
CAS 165377-43-5
Axon Medchem
Axon 1767
Supplier
Vendor
References
- K Matsuno et al. Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur. J. Pharmacol. 1996, 306(1-3), 271–279.
- G Skuza and Z Rogóz. The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats. J. Physiol. Pharmacol. 2006, 57(2), 217–229.
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