FK 960

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1607

CAS [133920-70-4]

MF C13H16FN3O2
MW 265.28

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

FK 960

Description

Somatostatin receptor agonist and also a 5-HT agonist; FK960 stimulates both serotonin and somatostatin production as a cognitive enhancer. However, its development for Alzheimer's disease (AD) was terminated in 2003

A Graul et al. FK-960, Congnition Enhancer. Drug. Fut. 1997, 22(8), 830-832.

N Matsuoka and TG Ainer. FK960 [N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate], a Novel Potential Antidementia Drug, Improves Visual Recognition Memory in Rhesus Monkeys... J. Pharmacol. Exp. Ther. 1997, 280(3), 1201-1209.

JP Hodgkiss and JS Kelly. Effect of FK960, a Putative Cognitive Enhancer, on Synaptic Transmission in CA1 Neurons of Rat Hippocampus. J. Pharmacol. Exp. Ther. 2001, 297(2), 620-628.

F Wang et al. Modulation of Ca2+Channel Currents by a Novel Antidementia Drug N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate (FK960) in Rat Hippocampal Neurons. J. Pharmacol. Exp. Ther. 2004, 308 (1), 120-126.

Somatostatin agonist

Chemical name

N-(4-acetylpiperazin-1-yl)-4-fluorobenzamide

Parent CAS No.

[133920-70-4]

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FK 960

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FK 960

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