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FK 960
Axon 1607
CAS:
133920-70-4
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C13H16FN3O2
- MW: 265.28
Description
Somatostatin receptor agonist and also a 5-HT agonist; FK960 stimulates both serotonin and somatostatin production as a cognitive enhancer. However, its development for Alzheimer's disease (AD) was terminated in 2003
More Information
| Parent CAS No. | 133920-70-4 |
|---|---|
| Chemical Name | N-(4-acetylpiperazin-1-yl)-4-fluorobenzamide |
| SMILES | C(C1C=CC(F)=CC=1)(=O)NN1CCN(C(=O)C)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C13H16FN3O2/c1-10(18)16-6-8-17(9-7-16)15-13(19)11-2-4-12(14)5-3-11/h2-5H,6-9H2,1H3,(H,15,19) |
| InChiKey | XTOKQKWTUYYVAO-UHFFFAOYSA-N |
| CID | 181428 |
| Short Description | Somatostatin agonist |
References
- N Matsuoka and TG Ainer. FK960 [N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate], a Novel Potential Antidementia Drug, Improves Visual Recognition Memory in Rhesus Monkeys... J. Pharmacol. Exp. Ther. 1997, 280(3), 1201-1209.
- JP Hodgkiss and JS Kelly. Effect of FK960, a Putative Cognitive Enhancer, on Synaptic Transmission in CA1 Neurons of Rat Hippocampus. J. Pharmacol. Exp. Ther. 2001, 297(2), 620-628.
- F Wang et al. Modulation of Ca2+Channel Currents by a Novel Antidementia Drug N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate (FK960) in Rat Hippocampal Neurons. J. Pharmacol. Exp. Ther. 2004, 308 (1), 120-126.
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