Odiparcil - SB 424323 | GSK 424323

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1536

CAS [137215-12-4]

MF C15H16O6S
MW 324.35

Purity: 99%
Soluble in DMSO

Odiparcil

Description

Orally active anti-thrombotic agent under clinical development, with limited hemorrhagic risk and a unique mechanism of action involving the induction of glycosaminoglycans (GAGs) biosynthesis; indirect thrombin inhibitor (via. Heparin cofactor II)

JR Toomey et al. A comparison of the β-D-xyloside, odiparcil, to warfarin in a rat model of venous thrombosis. J. Thrombosis and Haemostasis 2006, 4(9), 1989-1996.

VV Upreti et al. Determination of endogenous glycosaminoglycans derived disaccharides in human plasma by HPLC: Validation and application in a clinical study. J. Chromatography B. 2006, 831 (1-2), 156-162.

BI Eriksson and DJ Quinlan. Oral anticoagulants in development: focus on thromboprophylaxis in patients undergoing orthopaedic surgery. Drugs. 2006, 66(11), 1411-29.

Thrombin inhibitor (via Heparin CoFII)

Chemical name

7-((2R,3R,4S,5S)-tetrahydro-3,4,5-trihydroxy-2H-thiopyran-2-yloxy)-4-methyl-2H-chromen-2-one

Parent CAS No.

[137215-12-4]

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Odiparcil - SB 424323 | GSK 424323

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