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MPTP hydrochloride
- Parent CAS: 28289-54-5
- Soluble in water
- MF: C12H15N.HCl
- MW: 209.72
Description
MPTP is a dopaminergic neurotoxin used to model Parkinsonian neurodegeneration through selective injury of nigrostriatal dopamine neurons. Its metabolite MPP+ disrupts mitochondrial function in susceptible dopaminergic cells.
MPTP-based models are widely used to study dopamine neuron vulnerability, substantia nigra degeneration, mitochondrial toxicity and Parkinson's disease-related motor pathology. The compound should be handled only under appropriate controlled laboratory conditions.
MPTP hydrochloride is the preferred water-soluble salt form of MPTP for laboratory use.
Key Features
- Dopaminergic neurotoxin
- Models nigrostriatal dopamine neuron degeneration
- Linked to mitochondrial dysfunction through MPP+
- Relevant for Parkinsonian neurodegeneration research
- Water soluble
Applications
- Parkinson's disease model studies
- Dopamine neuron toxicity research
- Mitochondrial dysfunction and neurodegeneration assays
- Neuroprotective compound screening
Remark: Given its potent neurotoxicity, MPTP requires careful sourcing and controlled laboratory handling. Axon Medchem supplies MPTP hydrochloride, the non-lipophilic and stable salt form of MPTP, together with appropriate documentation to support responsible research use.
More Information
| Parent CAS No. | 28289-54-5 |
|---|---|
| Chemical Name | 1-Methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine hydrochloride |
| SMILES | C1C=CC(C2=CCN(C)CC2)=CC=1.Cl |
| MFCD | MFCD00012790 |
| InChi | InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H |
| InChiKey | KOWJANGMTAZWDT-UHFFFAOYSA-N |
| CID | 161406 |
| Short Description | DA neurotoxin |
