Cytostatin sodium salt
- NSC 675266
Axon N0018
- Parent CAS: 156856-30-3
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C21H32NaO7P
- MW: 450.44
Description
Protein Phosphatase 2A (PP2A) specific inhibitor, inhibits cancer cell adhesion to extracellular matrix.
Source information: Streptomyces sp. MJ654-NF4
More Information
| Parent CAS No. | 156856-30-3 |
|---|---|
| Chemical Name | Sodium (2S,5S,6S,7S,8Z,10Z,12E)-7-hydroxy-6-methyl-2-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)tetradeca-8,10,12-trien-5-yl hydrogenphosphate |
| SMILES | C1=C[C@H](C)[C@H]([C@@H](C)CC[C@@H]([C@@H](C)[C@@H](O)/C=CC=C/C=C/C)OP([O-])(O)=O)OC1=O.[Na+] |&1:2,4,5,9,10,12,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | Protein Phosphatase 2A (PP2A) specific inhibitor |
References
- M Amemiya et al. Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo). 1994 May;47(5):536-40.
- M Kawada et al. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. Biochim Biophys Acta. 1999 Nov 11;1452(2):209-17.
