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Eact
Axon 2576
CAS:
461000-66-8
Purity:
100%
- Soluble in DMSO
- MF: C22H24N2O5S
- MW: 428.5
Description
Strong activator of TMEM16A (ANO1; calcium activated chloride channel;CaCC) without elevating cytoplasmic Ca2+, producing outwardly rectifying currents (EC50 value 3 µM). Eact increases secretion by submucosal glands, as well as by airway surface cells exposed to a proinflammatory milieu; may be useful for treatment of cystic fibrosis (CF), dry mouth, and dry eye syndromes, and motility disorders of the gastrointestinal tract.
More Information
| Parent CAS No. | 461000-66-8 |
|---|---|
| Chemical Name | 3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenylthiazol-2-yl)benzamide |
| SMILES | C(N(CCOC)C1=NC(C2=CC=CC=C2)=CS1)(=O)C1=CC(OC)=C(OC)C(OC)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H24N2O5S/c1-26-11-10-24(22-23-17(14-30-22)15-8-6-5-7-9-15)21(25)16-12-18(27-2)20(29-4)19(13-16)28-3/h5-9,12-14H,10-11H2,1-4H3 |
| InChiKey | ZUXNHFFVQWADJL-UHFFFAOYSA-N |
| CID | 3173542 |
| Short Description | TMEM16A activator |
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