Bulk Inquiry
1-Deazaadenosine
Axon 2434
CAS:
14432-09-8
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C11H14N4O4
- MW: 266.25
Description
Inhibitor of adenosine deaminase (ADA; IC50 value 0.38 μM) 1-Deazaadenosine showed cytostatic activity against multiple cell lines in vitro.
More Information
| Parent CAS No. | 14432-09-8 |
|---|---|
| Chemical Name | (2R,3R,4S,5R)-2-(7-amino-3H-imidazo[4,5-b]pyridin-3-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol |
| SMILES | C12N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C=NC1=C(N)C=CN=2 |&1:2,4,7,9,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C11H14N4O4/c12-5-1-2-13-10-7(5)14-4-15(10)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1 |
| InChiKey | NVUDDRWKCUAERS-PNHWDRBUSA-N |
| CID | 159738 |
| Short Description | ADA inhibitor |
References
- S. Costanzi et al. 3'-deoxyribofuranose derivatives of 1-deaza and 3-deaza-adenosine and their activity as adenosine deaminase inhibitors. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1037-41.
- G. Cristalli et al. Improved synthesis and antitumor activity of 1-deazaadenosine. J Med Chem. 1987 Sep;30(9):1686-8.
- F. Seela et al. 1-Deazaadenosine: synthesis and activity of base-modified hammerhead ribozymes. Nucleic Acids Res. 1998 Feb 15;26(4):1010-8.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1631 | Vildagliptin |
From $66.00 |
| 2289 | ABT 702 |
From $143.00 |
| 2354 | Linagliptin |
From $99.00 |
| 2470 | Trelagliptin succinate |
From $159.50 |
Other Categories
Get a Quote for
Loading...
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.