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ARM1 hydrobromide
- Parent CAS: 68729-05-5
- Soluble in DMSO
- MF: C16H14N2S.HBr
- MW: 347.27
Description
Novel type of LTA4H inhibitor (IC50 value of ~0.5 μM in human neutrophils, and Ki value of 2.3 μM for purified LTA4H) that selectively blocks the conversion of LTA4 into proinflammatory mediator LTB4, although leaving the aminopeptidase activity intact for cleavage and inactivation of Pro-Gly-Pro. About LTA4H: Leukotriene A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc metalloenzyme that catalyzes biosynthesis of the proinflammatory mediator, LTB4, implicated in chronic inflammatory diseases. Recently, the chemotactic tripeptide Pro-Gly-Pro was identified as the enzyme’s endogenous peptidase substrate.
More Information
| Parent CAS No. | 68729-05-5 |
|---|---|
| Chemical Name | 4-(4-benzylphenyl)thiazol-2-amine hydrobromide |
| SMILES | S1C=C(C2=CC=C(CC3=CC=CC=C3)C=C2)N=C1N.Br |
| MFCD | MFCD06653257 |
| InChi | InChI=1S/C16H14N2S.BrH/c17-16-18-15(11-19-16)14-8-6-13(7-9-14)10-12-4-2-1-3-5-12;/h1-9,11H,10H2,(H2,17,18);1H |
| InChiKey | JNODWABIDXRUJK-UHFFFAOYSA-N |
| CID | 16495486 |
| Short Description | LTA4H inhibitor |
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