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NEO214
- Rolipram-POH
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C27H35NO5
- MW: 453.57
Description
NEO214 is a BBB penetrable autophagy inhibitor and a covalent conjugation of the natural monoterpene perillyl alcohol (POH) to Rolipram (Axon 1212). NEO214-induced cytotoxicity involves apoptosis triggered by endoplasmic reticulum (ER) stress, as well as activating the Death Receptor 5 (DR5)/TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) pathway.
More Information
| Parent CAS No. | 1361198-80-2 |
|---|---|
| Chemical Name | ((S)-4-(Prop-1-en-2-yl)cyclohex-1-enyl)methyl 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylate |
| SMILES | N1(C(OCC2CC[C@H](C(C)=C)CC=2)=O)CC(C2=CC=C(OC)C(OC3CCCC3)=C2)CC1=O |&1:7,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C27H35NO5/c1-18(2)20-10-8-19(9-11-20)17-32-27(30)28-16-22(15-26(28)29)21-12-13-24(31-3)25(14-21)33-23-6-4-5-7-23/h8,12-14,20,22-23H,1,4-7,9-11,15-17H2,2-3H3/t20-,22?/m1/s1 |
| InChiKey | JDWAOYHBJSFPSD-PSDZMVHGSA-N |
| CID | 56846913 |
| Short Description | Autophagy inhibitor |
References
- TC Chen et al. Induction of Pro-Apoptotic Endoplasmic Reticulum Stress in Multiple Myeloma Cells by NEO214, Perillyl Alcohol Conjugated to Rolipram. Int J Mol Sci. 2018 Jan 17;19(1):277.
- HY Cho et al. The Rolipram-Perillyl Alcohol Conjugate (NEO214) Is A Mediator of Cell Death through the Death Receptor Pathway. Mol Cancer Ther. 2019 Mar;18(3):517-530.
- M Ou et al. Inhibition of autophagy and induction of glioblastoma cell death by NEO214, a perillyl alcohol-rolipram conjugate. Autophagy. 2023 Dec;19(12):3169-3188.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1212 | Rolipram |
From $77.00 |
| 1229 | (R)-(-)-Rolipram |
From $121.00 |
| 1432 | (S)-(+)-Rolipram |
From $126.50 |
| 2327 | NEO 212 |
From $132.00 |
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