Bulk Inquiry
SC 26196
- PF 06341724
Axon 2112
CAS:
218136-59-5
Purity:
99%
- Soluble in DMSO
- MF: C27H29N5
- MW: 423.55
Description
Selective Δ6-desaturase inhibitor (IC50 = 0.2 µM in vitro; >100 fold selective over Δ5- and Δ9-desaturases), an enzyme essential for the synthesis of arachidonic acid. It showed anti-inflammatory effects to the same extent as indomethacin or essential fatty acid deficiency in established mouse models
More Information
| Parent CAS No. | 218136-59-5 |
|---|---|
| Chemical Name | 2,2-diphenyl-5-(4-(pyridin-3-ylmethyleneamino)piperazin-1-yl)pentanenitrile |
| extra_info | . |
| SMILES | N1(CCCC(C2=CC=CC=C2)(C2=CC=CC=C2)C#N)CCN(/N=C/C2=CC=CN=C2)CC1 |
| MFCD | MFCD11226148 |
| InChi | InChI=1S/C27H29N5/c28-23-27(25-10-3-1-4-11-25,26-12-5-2-6-13-26)14-8-16-31-17-19-32(20-18-31)30-22-24-9-7-15-29-21-24/h1-7,9-13,15,21-22H,8,14,16-20H2/b30-22+ |
| InChiKey | QFYKXKMYVYOUNJ-JBASAIQMSA-N |
| CID | 9845201 |
| Short Description | Δ6-desaturase inhibitor |
References
- MG Obukowicz et al. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J. Pharmacol. Exp. Ther. 1998, 287(1), 157-166.
- MB Hansen-Petrik et al. Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis. Cancer Lett. 2002, 175(2), 157-163.
Other Categories
Get a Quote for
Loading...
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.