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Avibactam sodium
- NXL104
- Parent CAS: 1192500-31-4
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C7H10N3NaO6S
- MW: 287.23
Description
Avibactam sodium is a covalent and reversible β-lactamase inhibitor with potent activity against both class A and class C enzymes (IC50 value of 38 nM for KPC-2).
More Information
| Parent CAS No. | 1192500-31-4 |
|---|---|
| Chemical Name | Sodium (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate |
| SMILES | NC([C@@H]1CC[C@H]2N(OS([O-])(=O)=O)C(=O)N1C2)=O.[Na+] |&1:2,5,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C7H11N3O6S.Na/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15;/h4-5H,1-3H2,(H2,8,11)(H,13,14,15);/q;+1/p-1/t4-,5+;/m1./s1 |
| InChiKey | RTCIKUMODPANKX-JBUOLDKXSA-M |
| CID | 24944097 |
| Short Description | β-lactamase inhibitor |
References
- T Stachyra et al. In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases. J Antimicrob Chemother 2009 Aug;64(2):326-9.
- DE Ehmann et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.
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