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Zoniporide hydrochloride
- CP 597396 hydrochloride
Axon 2022
- Parent CAS: 241800-98-6
Purity:
99%
- Soluble in water and DMSO
- MF: C17H16N6O.HCl
- MW: 356.81
Description
Potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1); Zoniporide inhibits NHE1-dependent Na+ uptake (IC50: 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50: 0.25 nM)
More Information
| Parent CAS No. | 241800-98-6 |
|---|---|
| Chemical Name | N-carbamimidoyl-5-cyclopropyl-1-(quinolin-5-yl)-1H-pyrazole-4-carboxamide hydrochloride |
| extra_info | . |
| SMILES | N1(C2C=CC=C3C=2C=CC=N3)C(C2CC2)=C(C(NC(N)=N)=O)C=N1.Cl |
| MFCD | MFCD09971126 |
| InChi | InChI=1S/C17H16N6O.ClH/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H |
| InChiKey | JTEXNYIOROVPIR-UHFFFAOYSA-N |
| CID | 11962997 |
| Short Description | NHE1 inhibitor |
References
- DR Knight et al. A Novel Sodium-Hydrogen Exchanger Isoform-1 Inhibitor, Zoniporide, Reduces Ischemic Myocardial Injury in Vitro and in Vivo. J. Pharmacol. Exp. Ther. 2001, 297(1), 254-259.
- A Guzman-Perez et al. Discovery of zoniporide: A potent and selective sodium–hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. Bioorg. Med. Chem. Lett. 2001, 11(6), 803–807.
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