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CP 316819
Axon 1847
CAS:
186392-43-8
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C21H22ClN3O4
- MW: 415.87
Description
CP-316819 is a potent glycogen phosphorylase (GPase) inhibitor with an IC50 value of 40 nM against human liver GPα. CP‑316819 facilitates glycogen utilization in the brain, prevents neuronal cell death, and helps maintain normal brain electrical activity.
Glycogen phosphorylase is a key enzyme in glycogen metabolism and energy homeostasis. Inhibition of GPase has been investigated for metabolic disorders and neuroprotection, making CP-316819 a valuable tool for studies of glycogen metabolism, neuronal survival, and brain energy regulation.
Key Features
- Potent glycogen phosphorylase (GPase) inhibitor
- IC50: 40 nM against human liver GPα
- Facilitates glycogen utilization in the brain
- Prevents neuronal cell death
- Maintains brain electrical currents
Applications
- Glycogen metabolism research
- Brain energy homeostasis studies
- Neuroprotection and neuronal survival research
- Metabolic disease investigations
- Neuroscience and neurodegeneration models
More Information
| Parent CAS No. | 186392-43-8 |
|---|---|
| Chemical Name | 5-chloro-N-((2S,3R)-3-hydroxy-4-(methoxy(methyl)amino)-4-oxo-1-phenylbutan-2-yl)-1H-indole-2-carboxamide |
| SMILES | N1C2=C(C=C(Cl)C=C2)C=C1C(N[C@H]([C@H](C(=O)N(OC)C)O)CC1C=CC=CC=1)=O |&1:12,13,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H22ClN3O4/c1-25(29-2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h3-9,11-12,17,19,23,26H,10H2,1-2H3,(H,24,27)/t17-,19+/m0/s1 |
| InChiKey | WEQLRDLTRCEUHG-PKOBYXMFSA-N |
| CID | 10273347 |
| Short Description | Gpase inhibitor |
CP 316819
CP316819
CP-316819
glycogen phosphorylase inhibitor
GPase inhibitor
glycogen phosphorylase GPα
glycogen metabolism
brain energy metabolism
neuronal survival
neuroprotection
brain electrical activity
energy homeostasis
metabolic disorders
CAS 186392-43-8
Axon Medchem
Axon 1847
GPase
Glycogen phosphorylase
Enzymes
Supplier
Vendor
References
- SW Suh et al. Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(...). J. Pharmacol. Exp. Ther. 2007, 1, 45-50.
- DG Baker et al. Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle. Diabetes 2005, 54, 2453.
