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L-778123
Axon 4297
CAS:
183499-57-2
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C22H20ClN5O
- MW: 405.88
Description
L-778123 is a potent inhibitor of FPTase and GGPTase-I with IC50 values of 2 nM and 98 nM, respectively.
More Information
| Parent CAS No. | 183499-57-2 |
|---|---|
| Chemical Name | 4-((5-((4-(3-Chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile |
| SMILES | N1=CN(CC2=CC=C(C#N)C=C2)C(CN2CCN(C3=CC=CC(Cl)=C3)C(=O)C2)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H20ClN5O/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18/h1-7,10,12,16H,8-9,13-15H2 |
| InChiKey | JNUGFGAVPBYSHF-UHFFFAOYSA-N |
| CID | 216454 |
| Short Description | FPTase/GGPTase-I inhibitor |
References
- FO Onono et al. The Farnesyltransferase Inhibitor (FTI) L-778,123 Displays Promising Anti-Leukemia Activity. Blood 2008; 112 (11): 2627.
- RB Lobell et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-58.
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