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(+)-Kifunensine
- FR 900494
Axon 1730
CAS:
109944-15-2
Purity:
99%
- Soluble in water and DMSO
- MF: C8H12N2O6
- MW: 232.19
Description
A potent class I α-mannosidase inhibitor that inhibits the glycoprotein biosynthesis; inhibits both human endoplasmic reticulum α-mannosidase I and Golgi class I mannosidase with Ki value of 130 and 23 nM respectively
More Information
| Parent CAS No. | 109944-15-2 |
|---|---|
| Chemical Name | (5R,6R,7S,8R,8aS)-6,7,8-trihydroxy-5-(hydroxymethyl)tetrahydroimidazo[1,2-a]pyridine-2,3(1H,5H)-dione |
| MFCD | MFCD00270017 |
| Short Description | α-Mannosidase inhibitor |
References
- H Kayakiri et al. Structure of kifunensine, a new immunomodulator isolated from an actinomycete. J. Org. Chem. 1989, 54(17), 4015-4016.
- AD Elbein et al. Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J. Biol. Chem. 1990, 265(26), 15599-15605.
- KW Hering et al. A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum alpha-mannosidase I. J Org Chem. 2005, 70(24), 9892-9904.
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