Bulk Inquiry
Canagliflozin
- JNJ-28431754 - TA-7284
Axon 3122
CAS:
842133-18-0
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C24H25FO5S
- MW: 444.52
Description
Canagliflozin is a highly potent and selective SGLT2 inhibitor with an IC50 value of 2.2 nM (hSGLT2). Canagliflozin showed pronounced anti-hyperglycemic effects in high-fat diet fed KK (HF-KK) mice.
More Information
| Parent CAS No. | 842133-18-0 |
|---|---|
| Chemical Name | (2S,3R,4R,5S,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
| SMILES | C1C(C)=C(CC2SC(C3C=CC(F)=CC=3)=CC=2)C=C([C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=1 |&1:19,20,22,24,26,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1 |
| InChiKey | XTNGUQKDFGDXSJ-ZXGKGEBGSA-N |
| CID | 24812758 |
| Short Description | SGLT2 inhibitor |
References
- J Lee et al. Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: 1,3,4-Thiadiazolylmethylphenyl glucoside congeners. Bioorg Med Chem. 2010;18(6):2178-2194.
- S Nomura et al. Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus. J Med Chem. 2010;53(17):6355‐6360.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1634 | Remogliflozin |
From $165.00 |
| 3121 | Dapagliflozin |
From $66.00 |
| 3367 | Empagliflozin |
From $88.00 |
Other Categories
Get a Quote for
Loading...
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.