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A 357300 hydrochloride
Axon 1666
CAS:
369358-07-6
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C15H22ClN3O3S.HCl
- MW: 396.33
Description
Potent and reversible inhibitor of methionine aminopeptidase-2 (MetAP-2)
More Information
| Parent CAS No. | 369358-07-6 |
|---|---|
| Chemical Name | N'-((2S,3R)-3-amino-2-hydroxy-5-(isopropylthio)pentanoyl)-3-chlorobenzohydrazide hydrochloride |
| SMILES | C1(Cl)C=C(C(=O)NNC(=O)[C@@H](O)[C@H](N)CCSC(C)C)C=CC=1.Cl |&1:10,12,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C15H22ClN3O3S.ClH/c1-9(2)23-7-6-12(17)13(20)15(22)19-18-14(21)10-4-3-5-11(16)8-10;/h3-5,8-9,12-13,20H,6-7,17H2,1-2H3,(H,18,21)(H,19,22);1H/t12-,13+;/m1./s1 |
| InChiKey | VNVMAFFENQJYPK-KZCZEQIWSA-N |
| CID | 91826477 |
| Short Description | MetAP2 inhibitor |
References
- J Wang et al. Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2. Cancer Res. 2003, 63(22), 7861-7869.
- MJ Morowitz et al. Methionine aminopeptidase 2 inhibition is an effective treatment strategy for neuroblastoma in preclinical models. Clin. Cancer Res. 2005, 11(7), 2680-2685.
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