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ML346
- CID 767276
- Soluble in DMSO
- MF: C14H12N2O4
- MW: 272.26
Description
ML346 is an activator of Hsp70 (EC50 value of 4.6 μM; HeLa cell toxicity assay). ML346 induces HSF-1-dependent chaperone expression and restores protein folding in conformational disease models. These effects are mediated by novel mechanisms involving FOXO, HSF-1, and Nfr-2. ML346 has good chemical stability, is not reactive with excess glutathione, and is cell permeable.
More Information
| Parent CAS No. | 100872-83-1 |
|---|---|
| Chemical Name | 5-(3-(4-Methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione |
| SMILES | C1C=C(/C=C/C=C2/C(=O)NC(=O)NC/2=O)C=CC=1OC |
| MFCD | N.A. |
| InChi | InChI=1S/C14H12N2O4/c1-20-10-7-5-9(6-8-10)3-2-4-11-12(17)15-14(19)16-13(11)18/h2-8H,1H3,(H2,15,16,17,18,19)/b3-2+ |
| InChiKey | IXYLVJHFJKDHRM-NSCUHMNNSA-N |
| CID | 767276 |
| Short Description | Hsp70 activator |
References
- B Calamini et al. ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2012 Dec 17
- B Calamini et al. Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. 2011 Dec 25;8(2):185-96.
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