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HEI3090

Axon 3262
CAS:  2377167-56-9
  • Optical Purity:  99% e.e.
  • Soluble in DMSO and EtOH
  • MF:  C18H15Cl3N4O3
  • MW:  441.7

Description

HEI3090 is a positive modulator of the purinergic P2RX7 receptor that potentiates αPD-1 treatment to effectively control the growth of lung tumors in transplantable and oncogene-induced mouse models and triggers long lasting antitumor immune responses.

More Information

Parent CAS No. 2377167-56-9
Chemical Name (S)-N1-(6-Chloropyridin-3-yl)-N2-(2,4-dichlorobenzyl)-5-oxopyrrolidine-1,2-dicarboxamide
SMILES C1C(NC(N2C(=O)CC[C@H]2C(=O)NCC2C=CC(Cl)=CC=2Cl)=O)=CN=C(Cl)C=1 |&1:9,r|
MFCD N.A.
InChi InChI=1S/C18H15Cl3N4O3/c19-11-2-1-10(13(20)7-11)8-23-17(27)14-4-6-16(26)25(14)18(28)24-12-3-5-15(21)22-9-12/h1-3,5,7,9,14H,4,6,8H2,(H,23,27)(H,24,28)/t14-/m0/s1
InChiKey XFDLAUDFTNZPNJ-AWEZNQCLSA-N
CID 139534072
Short Description P2X7 activator

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