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BMS-502
Axon 4110
CAS:
2407854-18-4
Purity:
99%
- Soluble in DMSO
- MF: C27H22F2N6O3
- MW: 516.5
Description
BMS-502 is a first-in-class potent and selective dual DGKα/ζ lipid kinase inhibitor with IC50 values of 5 nM and 2 nM for DGKα and DGKζ, respectively. BMS-502 demonstrated dose-dependent immune stimulation in the mouse OT-1 model.
More Information
| Parent CAS No. | 2407854-18-4 |
|---|---|
| Chemical Name | 8-(4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)-5-methyl-7-nitro-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile |
| MFCD | N.A. |
| Short Description | DGKα/ζ inhibitor |
References
- M Wichroski et al. DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity. Sci Transl Med. 2023 Oct 25;15(719):eadh1892.
- L Chupak et al. Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization. ACS Med Chem Lett. 2023 Jun 12;14(7):929-935.
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