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GSK923295

Axon 3852
CAS:  1088965-37-0
  • Optical Purity:  Optically pure
  • Soluble in DMSO
  • MF:  C32H38ClN5O4
  • MW:  592.13

Description

GSK-923295 is a first-in-class high affinity antimitotic inhibitor of centromere-associated protein E (CENP-E), potently and allosterically inhibiting CENP-E ATPase activity with a Ki value of 3.2 nM. Display a broad-spectrum antiproliferative activity against a range of human tumor xenografts grown in nude mice, including models of colon, breast, ovarian, lung and other tumors.

More Information

Parent CAS No. 1088965-37-0
Chemical Name 3-Chloro-N-((S)-1-(2-(dimethylamino)acetamido)-3-(4-(8-((S)-1-hydroxyethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)propan-2-yl)-4-isopropoxybenzamide
extra_info Sold in collaboration with Chemietek
SMILES C1=CN2C=C(C3C=CC(C[C@@H](CNC(=O)CN(C)C)NC(=O)C4C=CC(OC(C)C)=C(Cl)C=4)=CC=3)N=C2C([C@@H](O)C)=C1 |&1:10,38,r|
MFCD N.A.
InChi InChI=1S/C32H38ClN5O4/c1-20(2)42-29-13-12-24(16-27(29)33)32(41)35-25(17-34-30(40)19-37(4)5)15-22-8-10-23(11-9-22)28-18-38-14-6-7-26(21(3)39)31(38)36-28/h6-14,16,18,20-21,25,39H,15,17,19H2,1-5H3,(H,34,40)(H,35,41)/t21-,25-/m0/s1
InChiKey WHMXDBPHBVLYRC-OFVILXPXSA-N
CID 46898058
Short Description CENP-E Inhibitor

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