Bulk Inquiry
PDD00017273
Axon 3795
CAS:
1945950-21-9
Purity:
98%
- Soluble in DMSO and EtOH
- MF: C23H26N6O4S2
- MW: 514.62
Description
PDD00017273 is a highly potent and selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with an IC50 value of 26 nM. By inhibiting PARG, PDD00017273 reverses the effects of PARP, leading to increased PAR accumulation. It exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. PDD00017273 is cell-permeable and cell-active to inhibit PARG with high efficiency but has limited bioavailability. It has proven highly useful as an in vitro and cellular tool to study DNA-damage pathways.
More Information
| Parent CAS No. | 1945950-21-9 |
|---|---|
| Chemical Name | 1-((1,3-Dimethyl-1H-pyrazol-5-yl)methyl)-N-(1-methylcyclopropyl)-3-((2-methylthiazol-5-yl)methyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide |
| SMILES | C1(S(=O)(=O)NC2(CC2)C)C=C2C(=O)N(CC3SC(C)=NC=3)C(=O)N(CC3N(C)N=C(C)C=3)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H26N6O4S2/c1-14-9-16(27(4)25-14)12-28-20-6-5-18(35(32,33)26-23(3)7-8-23)10-19(20)21(30)29(22(28)31)13-17-11-24-15(2)34-17/h5-6,9-11,26H,7-8,12-13H2,1-4H3 |
| InChiKey | IFWUBRBMMNTBRZ-UHFFFAOYSA-N |
| CID | 121398766 |
| Short Description | PARG inhibitor |
References
Other Categories
Get a Quote for
Loading...
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.