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AMZ30
- ML136
Axon 3682
CAS:
1313613-09-0
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C19H12FN3O6S2
- MW: 461.44
Description
AMZ30 is a potent, selective and covalent inhibitor of protein phosphatase methylesterase-1 (PME-1) with an IC50 value of 600 nM.
More Information
| Parent CAS No. | 1313613-09-0 |
|---|---|
| Chemical Name | (E)-2-(4-Fluorophenylsulfonyl)-3-(1-(3-nitrophenylsulfonyl)-1H-pyrrol-2-yl)acrylonitrile |
| SMILES | C1C([N+]([O-])=O)=CC(S(=O)(=O)N2C=CC=C2/C=C(/S(=O)(=O)C2C=CC(F)=CC=2)C#N)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H12FN3O6S2/c20-14-6-8-17(9-7-14)30(26,27)19(13-21)11-15-4-2-10-22(15)31(28,29)18-5-1-3-16(12-18)23(24)25/h1-12H/b19-11+ |
| InChiKey | GUCUORSUHTZMBW-YBFXNURJSA-N |
| CID | 44607965 |
| Short Description | PME-1 inhibitor |
References
- SA Labuzan et al. Inhibition of protein phosphatase methylesterase 1 dysregulates MAP kinase signaling and attenuates muscle cell differentiation. Gene. 2020 May 20;739:144515.
- DA Bachovchin et al. Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. J Med Chem. 2011 Jul 28;54(14):5229-36.
