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NGI-1
- ML414 - N-linked Glycosylation Inhibitor-1
Axon 3588
CAS:
790702-57-7
Purity:
98%
- Soluble in DMSO and EtOH
- MF: C17H22N4O3S2
- MW: 394.51
Description
NGI-1 is a potent and cell-permeable inhibitor of oligosaccharyltransferase (OST) with an AC50 value of 1.1 μM for inhibition of N-linked glycosylation. NGI blocks the transfer of mature glycan precursors to recipient proteins. Moreover, NGI-1 blocks cell surface localization and signaling of the EGFR glycoprotein, but selectively arrests proliferation in only those cell lines that are dependent on EGFR (or FGFR) for survival. NGI-1 also exhibits pan-flaviviral activity.
More Information
| Parent CAS No. | 790702-57-7 |
|---|---|
| Chemical Name | 5-(N,N-Dimethylsulfamoyl)-N-(5-methylthiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide |
| SMILES | C1C(S(=O)(=O)N(C)C)=CC=C(N2CCCC2)C=1C(=O)NC1=NC=C(C)S1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H22N4O3S2/c1-12-11-18-17(25-12)19-16(22)14-10-13(26(23,24)20(2)3)6-7-15(14)21-8-4-5-9-21/h6-7,10-11H,4-5,8-9H2,1-3H3,(H,18,19,22) |
| InChiKey | QPKGRLIYJGBKJL-UHFFFAOYSA-N |
| CID | 2519269 |
| Short Description | Oligosaccharyltransferase inhibitor |
NGI-1
Oligosaccharyltransferase inhibitor
ML414
N-linked Glycosylation Inhibitor-1
NGI1
NGI 1
ML 414
ML-414
CAS 790702-57-7
Axon Medchem
Axon 3588
Oligosaccharide
Hexosyl-transferases
Inhibitor
Enzymes
Non-small cell lung cancer cells
Senescence
receptor tyrosine kinase-dependent tumors
OST
Supplier
Vendor
References
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