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PRL-3 inhibitor
- BR1
Axon 3436
CAS:
893449-38-2
Purity:
98%
- Soluble in DMSO
- MF: C17H11Br2NO2S2
- MW: 485.21
Description
PRL-3 inhibitor is a selective inhibitor of PRL-3 with an IC50 value of 0.9 μM. PRL-3 inhibitor strongly inhibited the migration and invasion of PRL-3 overexpressing colon cancer cells without exhibiting cytotoxicity.
More Information
| Parent CAS No. | 893449-38-2 |
|---|---|
| Chemical Name | 5-(5-Bromo-2-(2-bromobenzyloxy)benzylidene)-2-thioxothiazolidin-4-one |
| SMILES | C1(Br)C=C(/C=C2/C(=O)NC(=S)S/2)C(OCC2C=CC=CC=2Br)=CC=1 |
| MFCD | MFCD11045303 |
| InChi | InChI=1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8- |
| InChiKey | HXNBAOLVPAWYLT-NVNXTCNLSA-N |
| CID | 11983303 |
| Short Description | PRL-3 inhibitor |
References
- JH Ahn et al. Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2996-9.
- G Min et al. Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3769-74.
