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TEAD inhibitor TM2
- Soluble in DMSO and EtOH
- MF: C26H33N3O3
- MW: 435.56
Description
TEAD inhibitor TM2 is a potent reversible pan-TEAD inhibitor with strong modulation of TEAD-YAP/TAZ transcriptional activities. TM2 exhibits strong inhibition of TEAD2 and TEAD4 auto-palmitoylation with IC50 values of 156 nM and 38 nM, respectively. Also, TM2 significantly inhibits YAP-dependent liver organoid growth ex vivo and inhibits proliferation of YAP-dependent cancer cells as a single agent or in combination with a MEK inhibitor.
More Information
| Parent CAS No. | 1008768-41-9 |
|---|---|
| Chemical Name | 4-(3-(2-Cyclohexylethoxy)benzoyl)-N-phenylpiperazine-1-carboxamide |
| SMILES | C1(OCCC2CCCCC2)C=C(C(N2CCN(C(=O)NC3C=CC=CC=3)CC2)=O)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C26H33N3O3/c30-25(22-10-7-13-24(20-22)32-19-14-21-8-3-1-4-9-21)28-15-17-29(18-16-28)26(31)27-23-11-5-2-6-12-23/h2,5-7,10-13,20-21H,1,3-4,8-9,14-19H2,(H,27,31) |
| InChiKey | LWLAYULJAJMPKG-UHFFFAOYSA-N |
| CID | 68301145 |
| Short Description | TEAD inhibitor |
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