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4-CPPC
Axon 3189
CAS:
29553-70-6
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C14H9NO6
- MW: 287.22
Description
4-CPPC is the first potent, selective and reversible inhibitor of pro-inflammatory protein macrophage migration inhibitory factor-2 (MIF-2 or D-DT) with a Ki value of 33 μM and an IC50 value of 27 μM. 4-CPPC shows competitive binding with a 13-fold selectivity for human MIF-2 versus human MIF-1.
More Information
| Parent CAS No. | 29553-70-6 |
|---|---|
| Chemical Name | 4-(3-Carboxyphenyl)pyridine-2,5-dicarboxylic acid |
| SMILES | C1C=CC(C2C(C(=O)O)=CN=C(C(=O)O)C=2)=CC=1C(=O)O |
| MFCD | N.A. |
| InChi | InChI=1S/C14H9NO6/c16-12(17)8-3-1-2-7(4-8)9-5-11(14(20)21)15-6-10(9)13(18)19/h1-6H,(H,16,17)(H,18,19)(H,20,21) |
| InChiKey | NBVHLJGGHJLTGM-UHFFFAOYSA-N |
| CID | 893698 |
| Short Description | MIF-2 inhibitor |
References
- G Pantouris et al. Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor. Biochemistry. 2018 Jul 3;57(26):3599-3605.
- PV Tilstam et al. A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity. J Biol Chem. 2019 Dec 6;294(49):18522-18531.
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