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BC-LI-0186
Axon 3108
CAS:
695207-56-8
Purity:
99%
- Soluble in DMSO
- MF: C22H27N3O4S
- MW: 429.53
Description
BC-LI-0186 is a specific inhibitor of the interaction between Leucyl-tRNA synthetase (LRS) and RagD (IC50 of 46.11 nM). BC-LI-0186 bound to LRS with a Kd value of 42.1 nM. BC-LI-0186 efficiently inhibited leucine-dependent mTORC1 activity and the growth of cancer cells that express drug-resistant MTOR mutations.
More Information
| Parent CAS No. | 695207-56-8 |
|---|---|
| Chemical Name | 4-(4-Isopropyl-2,3-dimethyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide |
| SMILES | C1(N2N(C)C(C)=C(C(C)C)C2=O)C=CC(S(NCCOC2C=CC=CC=2)(=O)=O)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H27N3O4S/c1-16(2)21-17(3)24(4)25(22(21)26)18-10-12-20(13-11-18)30(27,28)23-14-15-29-19-8-6-5-7-9-19/h5-13,16,23H,14-15H2,1-4H3 |
| InChiKey | SQYWMHPZMHDCHP-UHFFFAOYSA-N |
| CID | 4917788 |
| Short Description | LRS-RagD inhibitor |
References
- JH Kim et al. Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction. Nat Commun. 2017 Sep 29;8(1):732.
- H Choi et al. Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane. Biochem Biophys Res Commun. 2017 Nov 18;493(2):1129-1135.
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