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RBPJ inhibitor RIN1
- RIN1
Axon 3061
CAS:
2682114-39-0
Purity:
99%
- Soluble in DMSO
- MF: C17H14FN3O2
- MW: 311.31
Description
RBPJ inhibitor RIN1 is a potent, selective, first-in-class inhibitor of the transcription factor RBPJ. RBPJ inhibitor RIN1 inhibits RBPJ in both its activating (NOTCH) and inhibiting (SHARP) complexes. Consistent with disruption of NOTCH signaling, RBPJ inhibitor RIN1 inhibited the proliferation of hematologic cancer cell lines and promoted skeletal muscle differentiation from C2C12 myoblasts.
More Information
| Parent CAS No. | 2682114-39-0 |
|---|---|
| Chemical Name | 2-(2-Fluorophenoxy)-4-(1-methyl-1H-pyrazol-5-yl)benzamide |
| SMILES | C1C(C(N)=O)=C(OC2C(F)=CC=CC=2)C=C(C2N(C)N=CC=2)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H14FN3O2/c1-21-14(8-9-20-21)11-6-7-12(17(19)22)16(10-11)23-15-5-3-2-4-13(15)18/h2-10H,1H3,(H2,19,22) |
| InChiKey | MFSSHRCJKRDIOL-UHFFFAOYSA-N |
| CID | 146019721 |
| Short Description | RBPJ inhibitor |
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