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ASP 2905
Axon 2979
CAS:
792184-90-8
Purity:
98%
- Soluble in DMSO
- MF: C20H17FN8
- MW: 388.4
Description
ASP 2905 is a potent, selective and orally active inhibitor of the potassium channel KCNH3 (Kv12.2) with an IC50 value of 9.0 nM. ASP 2905 may enhance cognitive performance and shows potential in the treatment of attention deficit/hyperactivity disorder.
More Information
| Parent CAS No. | 792184-90-8 |
|---|---|
| Chemical Name | N2-(4-Fluorophenyl)-N4-phenyl-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine |
| SMILES | N1C(NC2C=CC=CC=2)=NC(NCC2N=CC=CN=2)=NC=1NC1C=CC(F)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H17FN8/c21-14-7-9-16(10-8-14)26-20-28-18(24-13-17-22-11-4-12-23-17)27-19(29-20)25-15-5-2-1-3-6-15/h1-12H,13H2,(H3,24,25,26,27,28,29) |
| InChiKey | APYUZVKHUKMAIJ-UHFFFAOYSA-N |
| CID | 46913817 |
| Short Description | KCNH3 inhibitor |
References
- S Takahashi et al. Neurochemical and neuropharmacological characterization of ASP2905, a novel potent selective inhibitor of the potassium channel KCNH3. Eur J Pharmacol. 2017 Sep 5;810:26-35.
- S Takahashi et al. The KCNH3 inhibitor ASP2905 shows potential in the treatment of attention deficit/hyperactivity disorder. PLoS One. 2018 Nov 21;13(11):e0207750.
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