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NVS-ZP7-4
Axon 2936
CAS:
2349367-89-9
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C28H28FN5OS
- MW: 501.62
Description
NVS-ZP7-4 is a ZIP7 inhibitor and the first reported chemical tool to probe the impact of modulating endoplasmic reticulum (ER) zinc levels and investigate ZIP7 (SLC39A7) as a novel druggable node in the Notch signaling pathway.
ZIP7 is an intracellular zinc transporter that regulates zinc release from the endoplasmic reticulum and contributes to cellular signaling processes. NVS-ZP7-4 provides a valuable tool for studying zinc homeostasis, ER function, and Notch pathway biology.
Key Features
- ZIP7 (SLC39A7) inhibitor
- First reported chemical probe targeting ZIP7
- Modulates endoplasmic reticulum zinc levels
- Investigates ZIP7 as a druggable target
- Useful tool for Notch pathway research
Applications
- ZIP7 and zinc transporter research
- Zinc homeostasis studies
- Endoplasmic reticulum biology research
- Notch signaling pathway studies
- Chemical biology and target validation research
More Information
| Parent CAS No. | 2349367-89-9 |
|---|---|
| Chemical Name | (S)-1-(2-(6-Fluorobenzo[d]thiazol-2-ylamino)-3-phenylpropyl)-1'H-spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one |
| SMILES | C1C=C2C3(CCN(C[C@@H](NC4=NC5C=CC(F)=CC=5S4)CC4C=CC=CC=4)CC3)NC(=O)NC2=CC=1 |&1:8,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C28H28FN5OS/c29-20-10-11-24-25(17-20)36-27(32-24)30-21(16-19-6-2-1-3-7-19)18-34-14-12-28(13-15-34)22-8-4-5-9-23(22)31-26(35)33-28/h1-11,17,21H,12-16,18H2,(H,30,32)(H2,31,33,35)/t21-/m0/s1 |
| InChiKey | FZOFDZMKSAUTHT-NRFANRHFSA-N |
| CID | 134823928 |
| Short Description | ZIP7 inhibitor |
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