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WNK Inhibitor 11
Axon 2896
CAS:
2123489-30-3
Purity:
98%
- Soluble in DMSO
- MF: C21H21Cl2N5OS
- MW: 462.4
Description
Selective allosteric WNK1 inhibitor (IC50 value of 0.004 µM) with nearly 1000-fold selectivity for WNK1 vs WNK4 and 57-fold selectivity for WNK1 vs WNK2.
More Information
| Parent CAS No. | 2123489-30-3 |
|---|---|
| Chemical Name | (5-Chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone |
| SMILES | C1(Cl)C=CC(CN2CCN(C(C3C=C(C4N=C(NC)SC=4)N=CC=3Cl)=O)CC2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H21Cl2N5OS/c1-24-21-26-19(13-30-21)18-10-16(17(23)11-25-18)20(29)28-8-6-27(7-9-28)12-14-2-4-15(22)5-3-14/h2-5,10-11,13H,6-9,12H2,1H3,(H,24,26) |
| InChiKey | MVXAYIXYYOVALX-UHFFFAOYSA-N |
| CID | 133080583 |
| Short Description | WNK1 inhibitor |
