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AS 1842856
Axon 2839
CAS:
836620-48-5
Purity:
99%
- Soluble in DMSO
- MF: C18H22FN3O3
- MW: 347.38
Description
AS 1842856 is an orally active, potent and selective inhibitor of Forkhead box protein O1 transcription factor (IC50 value of 33 nM). AS 1842856 reduces glucose production through the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. Therapeutic drug for treating type 2 diabetes.
More Information
| Parent CAS No. | 836620-48-5 |
|---|---|
| Chemical Name | 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| SMILES | N1(CC)C2=C(C(N)=C(F)C(NC3CCCCC3)=C2)C(=O)C(C(O)=O)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H22FN3O3/c1-2-22-9-11(18(24)25)17(23)14-13(22)8-12(15(19)16(14)20)21-10-6-4-3-5-7-10/h8-10,21H,2-7,20H2,1H3,(H,24,25) |
| InChiKey | MOMCHYGXXYBDCD-UHFFFAOYSA-N |
| CID | 72193864 |
| Short Description | FOXO1 inhibitor |
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