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SPT Imidazopyridine 1
Axon 2835
CAS:
1933533-18-6
Purity:
98%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C22H24N2O3
- MW: 364.44
Description
Potent and efficacious serine palmitoyl transferase (SPT) inhibitor (IC50 value of 5 nM) with a good in vitro profile and ADME characteristics. SPT Imidazopyridine 1 reduces plasma ceramides in rodents, has a slight trend toward enhanced insulin sensitization in DIO mice, and reduces triglycerides and raises HDL in cholesterol/cholic acid fed rats.
More Information
| Parent CAS No. | 1933533-18-6 |
|---|---|
| Chemical Name | 2-(4-(6-Heptanoylimidazo[1,2-a]pyridin-8-yl)phenyl)acetic acid |
| SMILES | C1(C(=O)CCCCCC)C=C(C2C=CC(CC(=O)O)=CC=2)C2=NC=CN2C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H24N2O3/c1-2-3-4-5-6-20(25)18-14-19(22-23-11-12-24(22)15-18)17-9-7-16(8-10-17)13-21(26)27/h7-12,14-15H,2-6,13H2,1H3,(H,26,27) |
| InChiKey | MMYRYMMKMUTPBB-UHFFFAOYSA-N |
| CID | 131954583 |
| Short Description | SPT inhibitor |
