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NCL-00017509
Axon 2728
CAS:
1507367-00-1
Purity:
100%
- Soluble in DMSO
- MF: C15H12N6O
- MW: 292.3
Description
NCL-00017509 is a potent kinase-selective irreversible Nek2 inhibitor (IC50 value of 56 nM) with promising drug-like properties.
More Information
| Parent CAS No. | 1507367-00-1 |
|---|---|
| Chemical Name | 2-(3-(6-Ethynyl-9H-purin-2-ylamino)phenyl)acetamide |
| SMILES | N1C(C#C)=C2N=CNC2=NC=1NC1C=C(CC(=O)N)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H12N6O/c1-2-11-13-14(18-8-17-13)21-15(20-11)19-10-5-3-4-9(6-10)7-12(16)22/h1,3-6,8H,7H2,(H2,16,22)(H2,17,18,19,20,21) |
| InChiKey | CJQGLUJHMXCLQY-UHFFFAOYSA-N |
| CID | 56944360 |
| Short Description | Nek2 Inhibitor |
References
- B Carbain et al. 118 2-arylamino-6-ethynylpurines as Potent Irreversible Inhibitors of the Mitotic Kinase Nek2. Eur J Cancer 2012; 48, Supplement 6:37.
- H Lebraud et al. Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org Biomol Chem. 2014 Jan 7;12(1):141-8.
