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YMU1
- Soluble in DMSO
- MF: C17H22N4O4S
- MW: 378.45
Description
Selective human thymidylate kinase (hTMPK; IC50 value 1.65 µM) inhibitor that lacks inhibitory effect on the activity of purified thymidine kinase 1 (TK1). YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. Blocking hTMPK by YMU1 attenuates the ATP binding-induced closed conformation that is required for phosphorylation of dTMP, and sensitizes cancer cells for low-dose doxorubicin chemotherapy.
More Information
| Parent CAS No. | 902589-96-2 |
|---|---|
| Chemical Name | ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate |
| SMILES | C1C(C)=C2C(=O)N(CC(=O)N3CCN(C(OCC)=O)CC3)SC2=NC=1C |
| MFCD | N.A. |
| InChi | InChI=1S/C17H22N4O4S/c1-4-25-17(24)20-7-5-19(6-8-20)13(22)10-21-16(23)14-11(2)9-12(3)18-15(14)26-21/h9H,4-8,10H2,1-3H3 |
| InChiKey | XXUFNNVFZFVKGP-UHFFFAOYSA-N |
| CID | 49878590 |
| Short Description | TMPK inhibtor |
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