Order

Size
Price
Stock
Qty

ZNF281 inhibitor ZIM

 - ZNF281 Interfering Molecule
Axon 4499
CAS:  N.A.
Purity:  99%
  • Soluble in DMSO
  • MF:  C20H13F6NO3S2
  • MW:  493.45

Description

ZNF281 inhibitor ZIM is the first ZNF281 inhibitor, and completely prevented anthracycline-mediated cardiotoxicity (AIC), enhanced lung tumor regression, and prevented lung metastasis in a metastatic melanoma model.

Key Features

  • First reported small-molecule inhibitor of ZNF281
  • Completely prevents anthracycline-induced cardiotoxicity in preclinical models
  • Enhances lung tumor regression
  • Reduces metastatic spread in melanoma models
  • First chemical probe for ZNF281 biology

Applications

  • ZNF281 biology and target validation studies
  • Cardio-oncology and anthracycline cardiotoxicity research
  • Cancer progression and metastasis investigations
  • Epithelial-mesenchymal transition (EMT) research
  • Integrated stress response and transcriptional regulation studies

More Information

Parent CAS No. N.A.
Chemical Name (Z)-5-((4-((3,5-Bis(trifluoromethyl)phenyl)methoxy)-3-methoxyphenyl)methylene)-2-thioxo-1,3-thiazolidin-4-one
SMILES C1C(C(F)(F)F)=CC(C(F)(F)F)=CC=1COC1=CC=C(/C=C2/C(=O)NC(=S)S/2)C=C1OC
MFCD N.A.
InChi InChI=1S/C20H13F6NO3S2/c1-29-15-6-10(7-16-17(28)27-18(31)32-16)2-3-14(15)30-9-11-4-12(19(21,22)23)8-13(5-11)20(24,25)26/h2-8H,9H2,1H3,(H,27,28,31)/b16-7-
InChiKey DUAKHZWJDLCWAF-APSNUPSMSA-N
Short Description ZNF281 inhibitor

Related Products

AXON ID NAME FROM PRICE
1863 CID 5951923

From $148.50

2642 GANT61

From $132.00

3361 BI-3802

From $143.00

3927 NVP-DKY709

From $242.00

4269 OICR-12694

From Inquiry

Other Categories

More Categories

Axon Ligands™ for Cell Signaling & Oncology

Axon Ligand™ for Stem Cell Research 

Axon Ligands™ for Epigenetic Research 

Loading...