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UNC9750 hydrochloride
Axon 4418
Recently added
- Parent CAS: 2967648-29-7
Purity:
98%
- Soluble in DMSO
- MF: C23H24N6O·HCl
- MW: 436.94
Description
UNC9750 hydrochloride is a second-generation, highly potent inositol phosphate multikinase (IPMK) inhibitor with an IC50 value of 31.6 nM. UNC9750 showed improved pharmacokinetic properties. Treatment of human U251-MG glioblastoma cells with UNC9750 produced a novel metabolic profile not previously observed in genetic loss-of-function studies of IPMK: UNC9750 decreased InsP5 levels, without affecting InsP6 abundance in 3H-inositol-labeled U251 glioblastoma cells.
Key Features
- Second-generation IPMK inhibitor
- IC50: 31.6 nM
- Improved pharmacokinetic properties
- Modulates intracellular inositol phosphate metabolism
- Chemical probe for IPMK target validation studies
Applications
- IPMK and inositol phosphate signaling research
- Phosphoinositide metabolism studies
- Cancer biology and glioblastoma research
- Cellular metabolism and signaling investigations
- Target validation and chemical biology studies
More Information
| Parent CAS No. | 2967648-29-7 |
|---|---|
| Chemical Name | 3-(3-(1-Cyclobutylpiperidin-4-yl)phenyl)-5-(1H-tetrazol-5-yl)-benzo[c]isoxazole hydrochloride |
| SMILES | C1=CC(C2NN=NN=2)=CC2=C(C3=CC(C4CCN(C5CCC5)CC4)=CC=C3)ON=C12.Cl |
| InChi | InChI=1S/C23H24N6O.ClH/c1-3-16(15-9-11-29(12-10-15)19-5-2-6-19)13-17(4-1)22-20-14-18(23-24-27-28-25-23)7-8-21(20)26-30-22;/h1,3-4,7-8,13-15,19H,2,5-6,9-12H2,(H,24,25,27,28);1H |
| InChiKey | IYKARRWMJMCFLL-UHFFFAOYSA-N |
| Short Description | IPMK inhibitor |
UNC9750 hydrochloride
UNC9750
UNC 9750
UNC-9750
IPMK inhibitor
inositol phosphate multikinase inhibitor
IPMK
inositol phosphate signaling
inositol phosphate metabolism
InsP5
InsP6
phosphoinositide signaling
inositol phosphates
cellular metabolism
signal transduction
chemical probe
target validation
glioblastoma
U251-MG
glioblastoma cells
cancer metabolism
cancer biology
phosphatidylinositol
EMT
epithelial-to-mesenchymal transition
CAS 2967648-29-7
Axon Medchem
Axon 4418
Enzymes
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