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UK122

Axon 4280
  • Parent CAS:  940290-58-4
Purity:  98%
  • Soluble in DMSO
  • MF:  C17H13N3O2.C2HF3O2
  • MW:  405.33

Description

UK122 is a potent and highly selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 value of 0.2 μM. UK122 inhibits uPA-mediated plasminogen activation, a key process involved in extracellular matrix degradation, tumor cell invasion, and metastasis.

The uPA/plasminogen system plays an important role in cancer progression, tissue remodeling, angiogenesis, and metastatic dissemination, making uPA a valuable target for oncology and metastasis research.

Key Features

  • Potent and highly selective and cell-permeable uPA inhibitor
  • IC50: 0.2 μM
  • Inhibits urokinase-type plasminogen activator activity
  • Useful tool compound for metastasis and cancer research
  • Targets the uPA/plasminogen pathway

Applications

  • uPA signaling and plasminogen activation studies
  • Cancer invasion and metastasis research
  • Tumor microenvironment investigations
  • Extracellular matrix remodeling studies
  • Pancreatic cancer and oncology research

More Information

Parent CAS No. 940290-58-4
Chemical Name 4-((5-Oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benzimidamide trifluoroacetate
SMILES C1=CC(/C=C2C(=O)OC(C3=CC=CC=C3)=N2)=CC=C1C(=N)N.OC(C(F)(F)F)=O
MFCD N.A.
InChi InChI=1S/C17H13N3O2.C2HF3O2/c18-15(19)12-8-6-11(7-9-12)10-14-17(21)22-16(20-14)13-4-2-1-3-5-13;3-2(4,5)1(6)7/h1-10H,(H3,18,19);(H,6,7)/b14-10+;
InChiKey KVCIDYPYQWLDKP-KMZJGFRYSA-N
CID 25134287
Short Description uPA inhibitor

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