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HSL119
Axon 4186
CAS:
2231745-56-3
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C30H27F3N6O
- MW: 544.57
Description
HSL119 is a potent and selective first-generation HUNK inhibitor (IC50 value of ∼1.7μM in JIMT-1 cells). HSL119 has significant efficacy toward treating HER2+ breast cancer, even those that are resistant to HER2 inhibitors.
More Information
| Parent CAS No. | 2231745-56-3 |
|---|---|
| Chemical Name | 3-((8-Amino-1,7-naphthyridin-5-yl)ethynyl)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide |
| SMILES | C1C(C#CC2C=CC=C(C(=O)NC3C=C(C(F)(F)F)C(CN4CCN(C)CC4)=CC=3)C=2)=C2C=CC=NC2=C(N)N=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C30H27F3N6O/c1-38-12-14-39(15-13-38)19-23-9-10-24(17-26(23)30(31,32)33)37-29(40)21-5-2-4-20(16-21)7-8-22-18-36-28(34)27-25(22)6-3-11-35-27/h2-6,9-11,16-18H,12-15,19H2,1H3,(H2,34,36)(H,37,40) |
| InChiKey | WBNIVQNHQROLSV-UHFFFAOYSA-N |
| CID | 169447817 |
| Short Description | HUNK inhibitor |
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