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TGN-073
Axon 3930
CAS:
877459-36-4
Purity:
99%
- Soluble in DMSO
- MF: C18H16N2O3S
- MW: 340.4
Description
TGN-073 is an AQP4 facilitator which enhanced glymphatic transport. Diffusion MRI measurements demonstrated an increase in the diffusive transport of water in the brain of TGN-073 treated rats.
More Information
| Parent CAS No. | 877459-36-4 |
|---|---|
| Chemical Name | N-(3-(Benzyloxy)pyridin-2-yl)benzenesulfonamide |
| SMILES | C1(S(NC2=NC=CC=C2OCC2=CC=CC=C2)(=O)=O)=CC=CC=C1 |
| MFCD | MFCD03839445 |
| InChi | InChI=1S/C18H16N2O3S/c21-24(22,16-10-5-2-6-11-16)20-18-17(12-7-13-19-18)23-14-15-8-3-1-4-9-15/h1-13H,14H2,(H,19,20) |
| InChiKey | JBHHMMLJGNLVNB-UHFFFAOYSA-N |
| CID | 4338178 |
| Short Description | AQP4 facilitator |
References
- VJ Huber et al. Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood-brain barrier: [17O]H2O JJVCPE MRI study. Neuroreport. 2018 Jun 13;29(9):697-703.
- A Alghanimy et al. The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI. PLoS One. 2023 Mar 15;18(3):e0282955.
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