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(R)-SKBG-1
Axon 3928
CAS:
2955634-67-8
- Optical Purity: 99.9% e.e.
- Soluble in DMSO
- MF: C22H26ClN3O6S
- MW: 495.98
Description
(R)-SKBG-1 is a covalent RNA-binding protein NONO ligand. (R)-SKBG-1 promoted NONO accumulation in nuclear foci and stabilized NONO–RNA interactions, supporting a trapping mechanism that may prevent compensatory action of paralog proteins PSPC1 and SFPQ. Also, (R)-SKBG-1 showed IC50 values of 3.1 and 5.5 μM for depleting AR-FL and AR-V7 mRNA, respectively. The inactive enantiomer (S)-SKBG-1 is available as Axon 3929.
More Information
| Parent CAS No. | 2955634-67-8 |
|---|---|
| Chemical Name | (R)-4-(2-Chloroacetyl)-N-(4-methoxybenzyl)-1-(4-methoxyphenylsulfonyl)piperazine-2-carboxamide |
| SMILES | N1(C(=O)CCl)CCN(S(=O)(=O)C2C=CC(OC)=CC=2)[C@@H](C(=O)NCC2C=CC(OC)=CC=2)C1 |&1:19,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | NONO ligand |
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