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C25-140
Axon 3846
CAS:
1358099-18-9
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C26H31N7O
- MW: 457.57
Description
C25-140 is a first-in-class TRAF6–Ubc13 inhibitor which reduces TRAF6–Ubc13 activity both in vitro and in cells. C25-140 impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells. Moreover, C25-140 ameliorated inflammation and improved disease outcomes of autoimmune psoriasis and rheumatoid arthritis in preclinical in vivo mouse models.
More Information
| Parent CAS No. | 1358099-18-9 |
|---|---|
| Chemical Name | 1-(4-Benzylpiperidin-1-yl)-3-(3,5-dimethyl-1-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl)propan-1-one |
| SMILES | C1(CCC(=O)N2CCC(CC3C=CC=CC=3)CC2)=C(C)N(C2C=CC3=NN=C(C)N3N=2)N=C1C |
| MFCD | N.A. |
| InChi | InChI=1S/C26H31N7O/c1-18-23(19(2)32(29-18)25-11-10-24-28-27-20(3)33(24)30-25)9-12-26(34)31-15-13-22(14-16-31)17-21-7-5-4-6-8-21/h4-8,10-11,22H,9,12-17H2,1-3H3 |
| InChiKey | HFKVRXVHZGBRKF-UHFFFAOYSA-N |
| CID | 53093165 |
| Short Description | TRAF6–Ubc13 inhibitor |
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