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Nitisinone
- Nitisone - NTBC - SC0735
Axon 3662
CAS:
104206-65-7
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C14H10F3NO5
- MW: 329.23
Description
Nitisinone is a potent, reversible and orally bioavailable inhibitor of 4-hydroxyphenyl pyruvate dioxygenase (4-HPPD) with an IC50 value of 173 nM.
More Information
| Parent CAS No. | 104206-65-7 |
|---|---|
| Chemical Name | 2-(2-Nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione |
| SMILES | C1C(=O)C(C(=O)C2C([N+]([O-])=O)=CC(C(F)(F)F)=CC=2)C(=O)CC1 |
| MFCD | MFCD01752192 |
| InChi | InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2 |
| InChiKey | OUBCNLGXQFSTLU-UHFFFAOYSA-N |
| CID | 115355 |
| Short Description | 4-HPPD inhibitor |
References
- AC Aktuglu-Zeybek et al. Nitisinone: a review. Orphan Drugs: Research and Reviews. 2017 January 31; 7: 25-35.
- M Laschi et al. Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria. ChemMedChem. 2016 Apr 5;11(7):674-8.
