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TAK-931
- Simurosertib
Axon 3605
CAS:
1330782-76-7
- Optical Purity: 100% e.e.
- Soluble in DMSO
- MF: C17H19N5OS
- MW: 341.43
Description
TAK-931 (Simurosertib) is an orally bioavailable, ATP competitive, potent and selective inhibitor of CDC7 (cell division cycle 7-related protein kinase) with IC50 < 0.3 nM, and highly selective on target when compared with other 308 kinases. It demonstrates strong antitumor activities in both in vitro and in vivo models.
More Information
| Parent CAS No. | 1330782-76-7 |
|---|---|
| Chemical Name | (S)-6-(3-Methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one |
| SMILES | C12SC(C3C(C)=NNC=3)=CC=1N=C([C@@]1([H])N3CCC(CC3)C1)NC2=O |&1:13,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H19N5OS/c1-9-11(8-18-21-9)14-7-12-15(24-14)17(23)20-16(19-12)13-6-10-2-4-22(13)5-3-10/h7-8,10,13H,2-6H2,1H3,(H,18,21)(H,19,20,23)/t13-/m0/s1 |
| InChiKey | XGVXKJKTISMIOW-ZDUSSCGKSA-N |
| CID | 135564531 |
| Short Description | CDC7 inhibitor |
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| AXON ID | NAME | FROM PRICE |
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| 3894 | LY-3177833 |
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